Dopamine and relapse to drug seeking

Drug wanting: behavioral sensitization and relapse to drug-seeking behavior.

Repeated exposure to drugs of abuse enhances the motor-stimulant response to these drugs, a phenomenon termed behavioral sensitization. Animals that are extinguished from self-administration training readily relapse to drug, conditioned cue, or stress priming. The involvement of sensitization in reinstated drug-seeking behavior remains controversial. This review describes sensitization and rein...

Review. Context-induced relapse to drug seeking: a review.

In humans, exposure to environmental contexts previously associated with drug intake often provokes relapse to drug use, but the mechanisms mediating this relapse are unknown. Based on early studies by Bouton & Bolles on context-induced 'renewal' of learned behaviours, we developed a procedure to study context-induced relapse to drug seeking. In this procedure, rats are first trained to self-ad...

Context-induced relapse to drug seeking: a review

In humans, exposure to environmental contexts previously associated with drug intake often provokes relapse to drug use, but the mechanisms mediating this relapse are unknown. Based on early studies by Bouton & Bolles on context-induced ‘renewal’ of learned behaviours, we developed a procedure to study context-induced relapse to drug seeking. In this procedure, rats are first trained to self-ad...

share of Pleasure seeking, positive affect, negative affect, and sense of self-efficacy in relapse to drug

The purpose of this study is to share of Pleasure seeking, positive affect, negative affect, and sense of self-efficacy in relapse to drug. This study design was Descriptive and correlational. The study population consisted of all addicts return to a drug relapse occurred in less than one year And referred to addiction treatment centers in Tehran in 1395 was the 8th District Improved convenient...

Neuroadaptations underlying relapse to heroin seeking